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Microbiology Immunology c8ed3d00

Genetic deficiency of complement factor causes:

A
Hereditary angioneurotic edema
B
SLE- an autoimmune disease
C
Pyogenic bacterial infections
D
All of the above
High-Yield Explanation
Ans: d (All of the above) Ref: Ananthanaraya 7th ed, p. 115Deficiency of complement components are associated with a variety of syndromesDeficiencySyndromeCl inhibitorHereditary angoneurotic edema (main mediator of edema is C2 kinin released)C1C2C4SLE & collagen vascular disordersC3 & C3b inactivatorRecurrent pyogenic infectionsC5-8Gram - ve bacteremiaC9No particular diseaseRemember: Treatment of hereditary angioneurotic oedema is infusion of FFP

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