First pathological change apparent in Nephrotic syndrome is

Most forms of primary GN and many of the secondary glomerular diseases in human beings have immunologic pathogenesis. This view is largely based on immunofluorescence studies of GN in humans which have revealed glomerular deposits of immunoglobulins and complement in patterns that closely resemble those of experimental models. The consequences of injury at different sites within the glomerulus in various glomerular diseases can be assessed when compared with the normal physiologic role of the main cells involved i.e. endothelial, mesangial, visceral epithelial, and parietal epithelial cells as well as of the GBM as summed up in Table 22.8.<\p> text book of pathology harshmohan 6th edition page 662