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Pharmacology Epilepsy c80a7448

Serious, adverse behavioral reactions, including hostility, aggression, and suicidal thoughts and behaviors are associated with which of the following drugs?

A
Pregabalin
B
Topiramate
C
Levetiracetam
D
Lamotrigine
High-Yield Explanation
Levetiracetam is a pyrrolidine, and is FDA-approved for adjunctive therapy for myoclonic, focal-onset, and generalized onset tonic-clonic seizures in adults and children as young as 4 years old. Its s/e includes: Somnolence, anxiety, confusion, imbalance, double vision, dizziness, GI distress or nausea, and weight gain. Adverse behavioral reactions, including hostility, aggression,and suicidal thoughts and behaviors, independent of clinical history of psychiatric disorder are also seen.

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