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Pharmacology Anesthesia c7748ed9

True statement regarding Bupivacaine is:

A
Used intravenously along with lignocaine
B
More cardiotoxic than lignocaine
C
Contraindicated in pregnancy
D
All of the above
High-Yield Explanation
Bupivacaine is more cardio toxic than Lignocaine as it more prone to prolong QTc interval and induce ventricular tachycardia or cardiac depression- should not be used for intravenous regional anesthesia. It has high lipid solubility: distributes more in tissues than in blood after spinal or epidural injection . Therefore less likely to reach foetus. Hence used widely in obstetrics . From Tripati 7th edition Page no 367

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