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A 15-year-old boy with Albright hereditary osteodystrophy (AHO) is rushed to emergency room with severe muscle cramps and convulsions. The child has a history of mental retardation. Laboratory studies reveal hypocalcemia and elevated blood levels of PTH. Which of the following distinguishes this patient's endocrinopathy from hypoparathyroidism seen in DiGeorge syndrome?

A
Abnormalities in cardiac conduction and contractility
B
Accelerated degradation of PTH
C
Decreased neuromuscular excitability
D
End-organ unresponsiveness to PTH
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