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Regarding Gilbert syndrome, true all except -

A
Causes cirrhosis
B
Autosomal dominant
C
Normal liver function test
D
Normal histology
High-Yield Explanation
Ans. is 'a' i.e., Causes cirrhosis Gilbert's Syndrome: -o It is an autosomal dominant condition.o It is characterized by unconjugated hyperbilirubinemia (normally the bilirubin is transported into liver cells by intracellular proteins. In the liver, bilirubin is conjugated. This conjugation is brought about by certain enzymes. In Gilbert s syndrome, these enzymes are absent which cause unconjugated hyperbilirubinemia),o The hyperbilirubinemia is usually precipitated by following conditions - Stress, Fatigue, Alcohol use, reduced calorie intake, intercurrent illness.o The hepatic biochemical tests are normal except for elevated bilirubin level (serum bilirubin concentration are usually < 3mg/dl)o The hepatic histology is normalo There is no association with cirrhosis.

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