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Microbiology Immunology c743216f

Which one of the following statements best describes immunoglobulin structure?

A
The amino acid sequence variation of the heavy chains is different than that observed in light chains
B
In humans, there are approximately twice as many Ig molecules with k and l chains
C
In the three-dimensional structure of Ig, there is little, if any, flexibility in the hinge region between the Fc and two Fab poions
D
IgM is a monomeric structure
High-Yield Explanation
Following is a schematic figure of Ig. Note that each peptide chain is drawn as a continuous line and attachments between heavy and light chains are noted by solid bars. There appears to be considerable flexibility in the hinge region between the Fc and the two Fab poions of the molecule. This allows the molecule to assume either a T shape or a Y shape. Myeloma proteins have been widely used for Ig structural studies. The basic immunoglobulin structure.The unit consists of two identical light polypeptide chains and two identical heavy polypeptide chains linked together by disulphide bonds Reference: Ananthanarayan and Paniker&;s Textbook of Microbiology Tenth edition .

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