Pathology General pathology c7273819

What is the pathogenetic mechanism of HPV in causing cervical carcinoma?

Down regulation of 16INK4 protein

Degradation of cyclin D1

Genomic instability of E6 and E7

Up regulation of BCL2

High-Yield Explanation

Reference : Robbins basic pathology 9th edition : the oncogene city of HPV is related to the expression of two viral oncoproteins,E6 and E7 they bind to Rb and p53,respectively neutralizing their function

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What is the pathogenetic mechanism of HPV in causing cervical carcinoma?

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