Aspirin should be used with caution in the following groups of patients because of which of the following reason :

At therapeutic doses, Aspirin can cause hyperuricemia by decreasing the excretion of uric acid. It, therefore, should not be used in patients with gout. It also decreases the uricosuric action of probenecid. At high doses (>5 g/ d), it increases the excretion of uric acid, but such high doses are not tolerated. Aspirin is contraindicated in children (<12 yrs old) due to increased risk of Reye's syndrome, which is a type of he­patic encephalopathy. It should be avoided in diabetics because of risk of hypoglycemia It should be avoided in pregnancy because it may be responsible for low birth weight babies, however, it does not cause congenital malformations.