The parenteral administration of streptokinase

Streptokinase (SK) is thrombolytic (or fibrinolytic) because it activates plasminogen, resulting in the increased formation of plasmin. Its efficacy is equivalent to that of tissue plasminogen activator (t-PA), but SK is not clot-specific. All thrombolytics can cause bleeding, which may be counteracted to some extent by administration of antifibrinolysins, such as aminocaproic acid.