Full 2L QBank
Pharmacology JIPMER 2017 c635f1d3

Which of the following statement is false regarding Leflunomide:

A
Used in treatment of Rheumatoid ahriti
B
Act by inhibiting IMP dehydrogenase enzyme
C
Inhibits proliferation of T and B cells
D
It is contraindicated in pregnancy
High-Yield Explanation
Leflunomide is a prodrug of an inhibitor of pyrimidine synthesis by inhibiting enzyme dihydro orotate dehydrogenase thereby inhibiting proliferation of T and B cell. Toxicities include elevation of liver enzymes with some risk of liver damage, renal impairment, and teratogenic effects. It is approved only for rheumatoid ahritis at present, although studies are underway combining leflunomide with mycophenolate mofetil for a variety of autoimmune and inflammatory skin disorders, as well as preservation of allografts in solid organ transplantation. Mycophenolate mofetil: Act by inhibiting IMP dehydrogenase enzyme ,suppresses both B and T-lymphocyte.

Related Pharmacology MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now