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Pharmacology General c4cf636f

Which of the following drug used in gout act by conveing uric acid into allantoin ?

A
Colchicine
B
Allopurinol
C
Probenacid
D
Rasburicase
High-Yield Explanation
Ans: D. RasburicaseDrugs increasing metabolism of uric acid:Urate oxidase metabolizes insoluble uric acid to soluble allantoin in the birds'.This enzyme is absent in humans.Rasburicase (a recombinant urate oxidase) is used for this Purpose.PEGylateil uricase (pegloticase) is another similar drug.

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