Pediatrics Growth, Development, and Behavior c41e7410 What is the most probable cause of large head in this child? A Osteogenesis imperfecta B Mucopolysaccharidosis C Hydrocephalus D Cerebral gigantism High-Yield Explanation c. HydrocephalusLarge head in an infant with venous prominences over scalp and presence of 'setting-sun sign', suggest hydrocephalus.