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Pathology Central Nervous System c3fa70eb

Negri bodies are abundant in the following cells except?

A
Subcortical white matter
B
Purkinje cells
C
Hippocampus
D
Basal ganglia
High-Yield Explanation
Ans. (a) Subcortical white matter(Ref: R 9th/pg 1277)*Most characteristic pathologic finding in CNS in Rabies is the formation of cytoplasmic inclusion bodies called Negri bodies Q (composed of finely fibrillar matrix and rabies virus particles)*They are most commonly seen in cerebellum (purkinje cells) & pyramidal neurons of hippocampus*Basal ganglia involvement is common*The prominence of early brain stem dysfunction Q distinguish it from other viral encephalitis.

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