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Biochemistry Glycogen Metabolism and Glycogen Storage c3ef46aa

Muscle cannot make use of glycogen for energy because of deficiency of-

A
Glucokinase
B
Phosphoglucomutase
C
G-6-phosphatase
D
Muscle phosphorylase
High-Yield Explanation
Ans. is 'c' i.e., G-6-phosphatase o Glucose-6-phosphatase is absent in muscles therefore, glucose-6-phosphate cannot be degraded to free glucose in muscles,o Moreover, glucose-6-phosphate cannot diffuse out of the muscles.o Therefore, muscle cannot provide glucose to maintain blood glucose level. Rather, muscle glycogen acts as a source of energy; the glucose-6-phosphate enters the glycolysis to produce energy.Difference between muscle and liver glycogenolysisMuscleLivero Little glucose is formed, since glucose-6-phosphatase is absento Free glucose forms by glucose-6-phosphataseo Stimulated by adrenaline, glucagon has no effecto Glucagon is major stimulator of glycogenolysiso Stimulated by AMP but inhibited by glucose-6-phosphateo No effect of AMP, but hepatic glycogen phosphorylase is inhibited by glucose

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