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Medicine General c356a6b8

Thyrotoxic periodic paralysis (TPP) is usually due to hypokalemia. It is best treated with:

A
Potassium
B
Magnesium
C
Hydration
D
Propranolol
High-Yield Explanation
Thyrotoxic periodic paralysis is due to hypokalemia. MUST KNOW Hypokalemia is profound and accompanied by hypophosphatemia and hypomagnesemia. MECHANISM: Direct and indirect activation of Na+,K+-ATPase Increased uptake of K+ by muscle and other tissues Inrease in beta adrenergic activity Propranolol (3 mg/kg) rapidly reverses the hypokalemia, hypophosphatemia, and paralysis. Ref: Harrison, Edition-18, page- 352.

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