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Medicine Disorders of Adrenal Gland c2c6e421

Causes of diffuse hyperpigmentation include all of the following except?

A
Busulfan administration
B
Nelsons syndrome
C
Addison disease
D
Hermansky-Pudlak Syndrome
High-Yield Explanation
Busulfan administration Busulfan, cyclophosphamide, 5-fluorouracil, and inorganic arsenic induce pigment production and cause diffuse hyperpigmentation Nelson's syndrome Increased ACTH (Which has paial MSH activity) due to bilateral adrenalectomy Addison's disease Increased ACTH (Which has paial MSH activity) due to destruction of adrenal coex and low coisol Hermanksy- Pudlak syndrome Autosomal recessive disorder which results in oculo-cutaneous albinism (decreased pigmentation), and bleeding problems due to a platelet abnormality (platelet storage pool defect)

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