The mechanism of action of tetracyclines involves:
High-Yield Explanation
- Chloramphenicol acts by inhibiting peptide bond formation. - Tetracyclines act by binding to 30S ribosome and inhibiting the binding of acyl tRNA to A site of mRNA-ribosome complex. - It enters bacteria by forming pores in the cell membrane and by active transpo which pumps it across the cell membrane. - Macrolides, Clindamycin and Quinpristine act by inhibiting translocation.