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Pathology General c10d7131

All of the following immunohistochemical markers are positive in the neoplotic cells of granulocytic sarcoma, EXCEPT:

A
CD 45 RO
B
CD 43
C
Myeloperoxidase
D
Lysozome
High-Yield Explanation
A variety of markers for myeloid precursors in granulocytic sarcoma are identified. CD43, lysozyme, myeloperoxidase and CD 15 are the most sensitive markers staining a large propoion of the cells of the majority of well-differentiated tumors. CD 45 RO is not mentioned as a immunohistochemical marker of granulocytic sarcoma. Ref: Manual of Diagnostic Antibodies For Immunohistology By Anthony Siew-Yin Leong, Kumarasen Cooper, F. Joel W.-M. Leong, 2002, Page 339.

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