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Pharmacology Cytotoxic Anticancer Drugs c103a7a9

Mechanism of action of vincristine in the treatment of ALL is:

A
Inhibition of topoisomerase II to cause breaks in DNA strands
B
Alkylation and cross linking DNA strands
C
Inhibition of DNA mediated RNA synthesis
D
Inhibition of polymerization of tubulin to form microtubules
High-Yield Explanation
Vinca alkaloids like vincristine and vinblastine act by inhibiting the formation of mitotic by spindle inhibiting polymerization of tubulin. These drugs are selective for M phase of cell cycle.

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