In DM type-II Insulin resistance develops due to

Ans. a (End organ target receptor insensitivity). (Ref. Harrison, Principles of Medicine, 18th/2109)DIABETES MELLITUSType 2 DM is usually characterized bya) Variable degree of insulin resistanceb) Impaired insulin secretionc) Increased glucose production# The distinct pathologic processes are end organ target receptor insensitivity and a genetic and metabolic defect in insulin secretion and action.# Amyloidosis of pancreas is also a cause.# Type 1A DM results from autoimmune beta-cell destruction (has tendency to develop ketosis)# While in Type IB DM the mechanism of destruction is not known.