Anesthetic agent known to cause pain on intravenous injection:

Ans: (d) PropofolRef: Stoelting's Pharmacology and Physiology in Anesthetic Practice, 4th editionPropofol: Causes pain on intravenous injection due to presence of egg lecithin in its commercial preparation.Etomidate - Pain and venous irritation has been virtually eliminated with the use of lipid emulsion vehicle and avoid in propylene glycol.Ketamine and Thipenthol Na are not emulsion preparations and do not cause pain on IV injection.Composition of 1% Propofol Emulsion:1% propofol o 10% soyabean oil2.25% Glycerol o 1.2% egg lecithin0.005% di sodium edetate (to prevent bacterial growth)Prevention of pain duration IV injection of Propofol:Should be given in large bore cannula and in running fluidAdd 1% lidocaine with 10 ml of propofol before injectionGive fentanyl before propofol injectionUse lipid based formulation of propofolFospropofol (Aquavan): Is a phosphorylated prodrug of propofolNo pain on IV injectionLonger shelf half lifeSlight longer peak effect and more prolong duration of action1 mg Fospropofol=0.54mg propofol