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Pathology Bleeding Disorders c05043e0

Platelet aggregation is caused by?

A
Nitrous oxide
B
Thromboxone A2
C
Aspirin
D
PGE2
High-Yield Explanation
Ans. (b). Thromboxone A2(Ref: Robbins 9th/pg 116-117)Thromboxone A2 (TXA2)It is produced by activated platelets and has prothrombotic propertiesIt is an Arachidonic acid metabolite of COX pathwayFunctions: It is a potent platelet aggregator & vasoconstrictorIts effect is neutralized by prostacyclin (PGI2)

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