Which virus is implicated in Burkitts lymphoma?

Explanation: BURKITT LYMPHOMA There are three clinical types: 1. African (endemic) Burkitt lymphoma. 2. Sporadic (nonendemic) Burkitt lymphoma. 3. Aggressive lymphomas associated with HIV. These 3 types are histologically identical. Morphology The tumor exhibits a high mitotic index and contains numerous apoptotic cells, the nuclear remnants of which are phagocytosed by interspersed benign macrophages. These phagocytes have abundant clear cytoplasm, creating a characteristic “starry sky” pattern. Immunophenotype These are tumors of mature B cells. It express surface IgM, CD 19, CD20, CD 10 and BCL6. a phenotype consistent with a germinal center B-cell origin. Unlike other tumors of germinal center origin, this does not express anti-apoptotic protein BCL2. Molecular Pathogenesis All forms of Burkin lymphoma are associated with translocations of the c-MYC gene on chromosome 8. The translocation partner is usually the IgH locus light-chain loci. All endemic tumors are latently infected with EBV. which is also present in about 25% of HIVassociated tumors and 15% to 20% of sporadic cases. Clinical Features Endemic Burkitt lymphoma often presents as a mass involving the mandible and shows an unusual predilection for involvement of abdominal viscera, particularly the kidneys, ovaries and adrenal glands. Sporadic Burkitt lymphoma most often appears as a mass involving the ileocecum and peritoneum. Burkitt lymphoma is very aggressive but responds well to intensive chemotherapy