Syndrome associated with increased risk of leukemia is:

Genetic disease association of Lympho-haematopoietic malignancies: Acute leukaemia occurs with increased frequency with a variety of congenital disorders such as: Down’s syndrome Bloom’s syndrome Klinefelter’s syndrome Wiskott-Aldrich’s syndrome Mohan H. Textbook of pathology. Jaypee Brothers Medical Publishers; 2015. Edition 7. Page 334