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Pharmacology Endocrinology bf16bd33

Flushing is common in patient taking which of the follwing oral hypoglycemic drug with alcohol:

A
Chlorprompamide
B
Phenformin
C
Glibenclamide
D
Tolazamide
High-Yield Explanation
Chlorpropamide is a first generation sulphonylurea. It causes cholestatic jaundice, intolerance to alcohol in predisposed subjects(flushing and a disulfiram like reaction). Disulfiram like reaction seen with: chlorpropomide, tolbutamide, metronidazole, gresiofulvin, cefoperazone, cefomandole etc (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 267)

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