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Physiology Renal physiology befdd7d9

The prime driving force for countercurrent multiplier system is

A
Medullary hyperosmolarity
B
Reabsorption of Na+ in thick ascending limb
C
Action of ADH aquaporin channels
D
Urea recycling
High-Yield Explanation
In juxtamedullary nephrons with longer loops and thin ascending limbs, the osmotic gradient is spread over a greater distance and the osmolality at the tip of the loop is greater. This is because the thin ascending limb is relatively impermeable to water but permeable to Na+ and Cl-. Therefore, Na+ and Cl- move down their concentration gradients into the interstitium, and there is additional passive countercurrent multiplication.Ref: Ganong&;s Review of Medical Physiology, 23rd edition, page no: 655

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