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Pharmacology General bef08226

All of the following are true about HMG CoA reductase inhibitors except:

A
CNS accumulation of simvastatin and lovastatin is high and less for pravastatin and fluvastatin
B
Simvastatin is rapidly and pravastatin is least metabolized.
C
Bioavailability is minimally modified when pravastatin is taken with food
D
Fibrinogen levels are increased by pravastatin
High-Yield Explanation
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