Early diagnosis of active hepatitis B infection is done by :

Answer is A (IgM Anti HBc Antibody): IgM Anti HBc Antibody is the most reliable marker of acute HBV infection IgM Anti HBc Antibody is known to be the most reliable marker of an acute HBV infection since it is detectable even during the so called serological gap and is charachteristically absent in chronic infections (IgG HBc Antibody is present in chronic infections)-Hepatology: Principles and Practice' 2m1/117 HBeAg HBeAg IgM anti-HBc IgG anti-HBc Anti-HBs Anti-HBe HBVDNA Interpretation Acute HBV +- - +++ Early phase Infectio ? - + + Window phase - - + + + Recovery phase Chronic HBV + - - + +- Inactive carrier state Infection + _ _ + + ++ HBeAg-chronic hepatitis + -+ +++ FIBeAg+chronic hepatitis HbsAg, hepatitis B surface antigen;HBeAg, hepatitis B e antigen:IgM, im nunoglobulin M;anti-HBc, hepatitis B core Antibody; IgG, immunoglobulin G; anti-HBs, hepatitis B surface antibody; anti-HBe, hepatitis B e antibody