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Pharmacology Anti-Fungal Drugs be8e62fc

Which of the following statements about fluconazole is most accurate?

A
It is highly effective in the treatment of aspergillosis
B
It does not penetrate the blood-brain barrier
C
Its oral bioavailability is less than that of ketoconazole
D
It inhibits demethylation of lanosterol
High-Yield Explanation
* Fluconazole (Azoles) act by inhibiting the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. * It has very good CNS penetration and oral bioavailability. * It is not very effective against aspergillosis (voriconazole is the drug of choice).
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