Chromosomal instability syndrome is

Immunohistochemistry : Used in diagnosis of abnormal cells such as those found in tumors also used to understand the distribution and localization of biomarkers and differentially expressed protiens in different parts of a biological tissue. Southern blotting : Used to detect DNA changes, e.g. whether genes have been deleted or rearranged. It is also used to detect RFLP. So it can detect gene expression. Northern blotting : Used to detect RNA level. So used to analyze pattern and level of gene expression in different tissue. Microarray : Can detect genomic changes as it measures many mRNA levels at once.