AFP is raised in all except:

As we have discussed earlier – AFP levels are raised in : Under estimated gestational age Decreased liqour Decreased birth weight of infant and decreased maternal weight IUD Multifetal pregnancy (The amount of AFP entering the maternal circulation is proportional to the number of fetuses). Defects which permit more release of AFP into maternal serum – Neural tube defects – Abdominal wall defects : omphalocele gastroschisis – Pilonidal cysts – Congenital skin defects Maternal causes: – Preeclampsia – Maternal hepatoma, teratoma, endodermal sinus tumor Shaw 14/e, p 380 Placental causes: – Chorioangioma of placenta – Placenta accreta – Abruptio placentae