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Anaesthesia General bd98d855

Mechanism of action of theophylline in Bronchial asthma include all of the following Except ?

A
Phosphodiesterase inhibition
B
Adenosine receptor antagonism
C
Increased histone deacetylation
D
Beta-2 receptor stimulation
High-Yield Explanation
Ans. is 'd' i.e., Beta-2 receptor stimulation Proposed mechanisms of action of theophylline Phosphodiesterase inhibition (Non selective) Adenosine receptor antagonism (A1, A2) Increased histone Deacetylase activity (|red efficacy of coicosteroids) Inhibition of intracellular calcium release Stimulation of catecholamine release Inhibition of NF - alpha Beta translocation into the nucleus (nuclear translocation) Mediator inhibition (Prostaglandins, TNF alpha)

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