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Pharmacology General bd619870

Cardiac conduction defect seen with Tricyclic antidepressants are due to-

A
NE & serotonin uptake inhibitor
B
Antimuscarinic action on hea
C
Only NE uptake inhibition
D
Both NE uptake inhibition and antimuscarinic action on hea
High-Yield Explanation
Ans. is 'd' i.e., Both NE uptake inhibition and antimuscarinic action on hea o The commonest cardiovascular effect of tricyclic antidepressant overdose is sinus tachycardia, which is attributable to the inhibition of norepinephrine reuptake and the anticholinergic action.

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