Pharmacology General Pharmacology bd25b297

Apparent volume of distribution (Vd) of a drug exceeds total body fluid volume, if a drug is:

Sequestrated in body tissues

Slowly eliminated from body

Poorly soluble in plasma

Highly bound to plasma proteins

High-Yield Explanation

Ans. (A) Sequestered in body tissues(Ref: KDT 8th/e p24)* Apparent volume of distribution (Vd ) is more for drugs sequestered in tissues.* Lipid insoluble drugs do not enter cells, Vd approximates ECF volume.

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