A 48 years of woman was admitted with a history of weakness for two months. On examination cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5g/di. Platelet count 237x 109/L, and total leukocyte count 40x109/L, which include 80% mature lymphoid cell with coarse clumped chromatin. Bone marrow revealed dnodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20 and were negative for CD79B and FMC(-7). Which one of the following statements is not true about this disease?