Investigation of choice in whole-body imaging in metastasis is

Whole body diffusion weighted imaging along with anatomical images such as T1 and T2 can be very useful for the evaluation of malignant tumors/metastasis alternative to PET/CT.The disadvantage is that it is time-consuming investigation The basic principle of DWI is based on the Brownian motion of water molecules which takes place in the body and it utilizes motion sensitizing gradients to study this motion.It provides unique information at a microstructural and functional level which can be used to characterize cellular dense lesions and this has applications in oncology. It can be performed rather quickly and does not require the use of exogenous contrast agents. Diffusion can be assessed both qualitatively and quantitatively. It is quantified by the parameter called Apparent Diffusion Coefficient (ADC).(Ref: Grainger and Allison&;s diagnostic radiology 6th edition, chapter 68)