Antihistaminic not much preferable in motion sickness among the following is:

1st generation drugs better treat motion sickness than 2nd gen drugs due to high sedating nature Fexofenadine is a 2nd gen. antihistaminic Promethazine, diphenhydramine, dimenhydrinate, and meclozine have prophylactic value in milder types of motion sickness; should be taken one hour before staing journey. Promethazine can also be used in morning sickness, drug-induced and postoperative vomiting, radiation sickness.