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Pharmacology General pharmacology bcd28813

Low Vd means

A
The drug has low half life
B
The drug does not accumulate in tissues
C
The drug has low bioavailability
D
The drug has weak plasma protein binding
High-Yield Explanation
The volume of distribution (V) relates the amount of drug in the body to the concentration of drug (C) in blood or plasmaVd = amount of drug in body/concentration of drug (C)Drugs with low volumes of distribution have much lower concentrations in extravascular tissue than in the vascular compament.Katzung Pharmacology 12th edition Pg: 38

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