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Pharmacology General bc745f5e

Which of the following drugs is topoisomerase I inhibitor?

A
Doxorubicin
B
Irinotecan
C
Etoposide
D
Vincristine
High-Yield Explanation
Camptothecin derivatives like topotecan and irinotecan act by inhibiting topoisomerase-I whereas Epipodophyllotoxins (etoposide and teniposide) and anthracyclines (doxorubicin, daunorubicin etc.) act by inhibiting topoisomerase-II.

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