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Pathology General bc451ecf

A 60 year old male presented with acute chest pain of 4 hours duration. Electrocardiographic examination revealed new Q wave with ST segment depression. He succumbed to his illness within 24 hours of admission. The heart revealed presence of a transmural haemorrhagic area over the septum and anterior wall of the left ventricle. Light microscopic examination is most likely to reveal -

A
Edema in between normal myofibres
B
Necrotic myofibres with presence of neutrophils
C
Coagulative necrosis of the myocytes with presence of granulation tissue
D
Infiltration by histiocytes with haemosiderin laden macrophages
High-Yield Explanation
The patient in the question succumbed to myocardial infarction after about 28 hours of the attack. After twenty-four hours of the attack light microscopy shows coagulative necrosis of myofibrils with loss of nuclei and striations along with an interstitial infiltrate of neutrophils. For details, see the table of morphological changes of MI in text.

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