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Pediatrics Growth and development bc2e3728

Triple test for the diagnosis of Down&;s syndrome includes all of the following except:

A
Beta hcg
B
Alpha-fetoprotein
C
Inhibin A
D
Serum oestriol level
High-Yield Explanation
lnhibin A is not included in Triple test , its is a pa of Quadruple test . Triple test AFP+HCG+UE3 Quadruple test Triple test+Inhibin A Combined test (first-trimester screening) PAPPA+HCG+Nuchal translucency Intergrated test First-trimester screening+Quadruple test The most sensitive is the integrated test (94-96% detection rate) The risk for abnormal offpspring for a carrier of balanced chromosomal translocation of 21:21 is 100% Ref: Nelson textbook of pediatrics 21st edition pgno: 661

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