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True about keloid:

A
Wide local excision is treatment of choice
B
It will have more collagen and vascularity
C
Will not spread beyond wound site
D
Elevated levels of growth factor is not seen
High-Yield Explanation
Ref. Sabiston Textbook of Surgery. Pg. 142   Keloid  is the type of abnormal scar formation  and it is most commonly confused with hypertrophic scar . Keloid scars resemble hypertrophic scars superficially in that they are elevated boundary of the original injury or incision . Males and females equally prone to keloid scars ,but dark skin types ,especially african genetic origin are 15 times more prone . Keloid has familial tendency and it spreads beyond wound site Similarity between keloid and hypertrophic scar is both involves abnormal collagen metabolism resulting in a higher than usual proportion of type 3 collagen and both associated with tissue hypoxia and sustained levels of TGF BETA 1 . Keloid contain thick collagen and have increased levels of epidermal hyaluronic acid, whereas hypertrophic scars have more nodular microscopic structure with fine collagen bundles and increased conc of alpha actin . Treatment -intralesional steriods injections .

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