Chronic Hemolysis from which of the following conditions may be associated with iron deficiency:

Answer is A (Paroxsmal cold Haemoglobinuria) Chronic hemolysis due to paroxysmal cold Haemoglobinuria may be associated with iron deficiency 'In chronic extravascular hemolysis iron is tenaciously conserved. In chronic intravascular hemolysis large amounts of iron are lost in the urine as free haemoglobin, muthemoglobin and hemosiderin and the patient may become iron deficient'- Hematology for Students. Amongst the options provided paroxysmal cold haemoglobinuria is a cause for intravascular hemolysis and hence the single best answer of choice Thalassemia, Hereditary spherocytosis and G6-PD deficiency are all associated with extravascular hemolysis and are likely to present with iron overload and not iron deficiency