Dapsone is used for treatment of bacterial and fungal infections as well as for immunomodulatory actions. What is mechanism of dapsone for these indication?
High-Yield Explanation
Sulfonamides (including Dapsone and PAS) : Competitively inhibit folic acid synthase enzyme as these are PABA analogues. Trimethoprim, Pyrimethamine : Inhibit Dihydro folate reductase enzyme (DHFRase). Inhibition of ergosterol in cell membrane (in fungus and leishmania): Amphotericin B.