Hyaline aeriosclerosis is seen in which of the following conditions: September 2008

Ans. B: HypeensionHyaline aeriolosclerosis refers to thickening of the walls of aerioles by the deposition of homogeneous pink hyaline material.It is a type of aeriolosclerosis which refers to hardening of aeriolar wall.It is encountered frequently in elderly patients, whether normotensive or hypeensive, hyaline aeriolosclerosis is more generalized and more severe in patients with hypeension.It is also common as pa of the characteristic microangiography in diabetes. It is often seen in kidney pathology.Lesions reflect leakage of plasma components across vascular endothelium and excessive extracellular matrix production by smooth muscle cells secondary to the chronic hemodynamic stress of hypeension.Hyaline aeriolosclerosis is a major morphologic characteristic of benign nephrosclerosis, in which the aeriolar narrowing causes diffuse impairment of renal blood supply, with loss of nephrons.The narrowing of the lumen can decrease renal blood flow and hence glomerular filtration rate leading to renin secretion and accentuating the underlying hypeension causing a perpetuating cycle