Troponin-T is a marker of -

MARKERS IN MYOCARDIAL INFARCTION Myoglobin Earliest marker to rise Rises within 1 hour Clears in 4-12 hours Poor specificity. Cardiac-specific troponin T (cTnT) and troponin I (cTnI) Normally NOT detectable in healthy individuals without MI Most sensitive cardiac biomarker Rise at 2 to 4 hours The peak at 48 hours Remain elevated upto 7-10 days Elevated in microinfarctions (NSTEMI), not in unstable angina. Creatine kinase (CK) CK rises within 4-8 hours Returns to normal in 48-72 hours Not specific, also rises in Muscle disease. Trauma. IM injections. Defibrillation CK MB isoenzyme is more cardiac specific CK MB also high in Myocarditis, Cardioversion. Cardiac surgery The ratio of CK MB mass: CK activity > 2.5 suggestive of a cardiac cause. Lactate dehydrogenase (LDH) Last marker to rise. LDH-1 is specific to cardiac tissue LDH-l/LDH-2 ratio is a good indicator of MI. Aspartate aminotransferase - Rarely used clincially.