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Pathology General baba36b0

The histological features of the celiac disease include all of the following Except -

A
Crypt hyperplasia
B
Increase in thickness of the mucosa
C
Increase in intraepithelial lymphocytes
D
Increase in inflammatory cells in lamina propria
High-Yield Explanation
Pathological features In celiac disease, the proximal intestine is commonly involved while in tropical sprue whole of the intestine is involved. Biopsy of the intestine in celiac sprue demonstrates. - Villous atrophy, loss of microvilli brush border - The crypts are hyperplastic and become elongated. - Presence of following cells on lamina propria → Plasma cells, Lymphocytes, Macrophages, Eosinophils, Mast cells - Remember that overall mucosal thickness remains same in celiac sprue Celiac disease is associated with dermatitis herpetiformis. Individuals with celiac disease have a higher incidence of malignancy → enteropathy-associated T-cell lymphoma (most common), small intestine adenocarcinoma.

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