The histological features of the celiac disease include all of the following Except -
High-Yield Explanation
Pathological features
In celiac disease, the proximal intestine is commonly involved while in tropical sprue whole of the intestine is involved.
Biopsy of the intestine in celiac sprue demonstrates.
- Villous atrophy, loss of microvilli brush border
- The crypts are hyperplastic and become elongated.
- Presence of following cells on lamina propria → Plasma cells, Lymphocytes, Macrophages, Eosinophils, Mast cells
- Remember that overall mucosal thickness remains same in celiac sprue
Celiac disease is associated with dermatitis herpetiformis.
Individuals with celiac disease have a higher incidence of malignancy → enteropathy-associated T-cell lymphoma (most common), small intestine adenocarcinoma.