Inhalational halogenated anesthetics may cause malignant hyperthermia in(372- KDT 6th) (Lippincott's 3rd pharmacology)

D. i.e. (Genetic defect in calcium channel at sarcoplasmic reticulum of the skeletal muscle) (372-KDT 6th)Malignant Hyperthermia - occurs in small population who have a genetic defect in the muscle (ryanodine receptor) calcium channel at the sarcoplasmic reticulum of the skeletal muscle.Which is triggered by halothane** to release massive Ca++ intracellularly causing persistent muscle contraction and increase heat production**. Succinylcholine** - accentuates the conditions.Treatment* Rapid external cooling* Bicarbonate infusion* 100% O2 inhalation* IV Dantrolene** 1. Thiopental** is a potent anesthetic but weak analgesic2. Nitrous oxide* - is potent analgesic but weak general anesthetic* Propofol is agent of choice for induction in susceptible individuals for malignant hyperthermia