On follow up study, elevated CA 125 in a case of epithelial ovarian tumor should be further evaluated with?

Ans. B. CT Scana. Evaluation of patients with suspected ovarian cancer should include measurement of serum levels of the tumor marker CA-125.b. CA-125 determinants are glycoproteins with molecular masses from 220to1000kDa, and a radioimmunoassay is used to determine circulating CA-125 antigen levels. Between 80 and 85% of patients with epithelial ovarian cancer have levels of CA-125_35U/mL.c. Other malignant tumors can also elevate CA-125 levels, including cancers of the endometrium, cervix, fallopian tubes, pancreas, breast, lung, and colon.d. Certain nonmalignant conditions that can produce moderate elevations of CA-125 levels include pregnancy, endometriosis, pelvic inflammatory disease, and uterine fibroids. About 1% of normal females have serum CA-125levels_35U/mL.